sonic hedgehog receptor ptc1 regulates cell cycle
| PAG Title | sonic hedgehog receptor ptc1 regulates cell cycle |
| PAG ID | WAG000418 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | Sonic Hedgehog (Shh) is a secreted protein identified genetically as an important developmental factor. Shh provides a morphogenic sigl in the developing CNS, organizing the spatial patterning of cells in the midbrain and inducing proliferation of neurol precursor cells in the developing cerebellum, neural tube and reti. Proliferative sigling by Shh is involved in the development of cancer, including specific brain and skin cancers such as basal cell carcinomas. Sonic hedgehog sigling may proceed by more than one mechanism. One sigling pathway is activated by Shh binding to Patched (Ptc-1) which releases inhibition of the GPCR Smoothened, activating the Shh sigling pathway and allowing progression through the G1 phase of the cell cycle. Shh can also affect progression through the G2/M transition. Patched binds to phosphorylated Cyclin B1, one component of the M-phase promoting factor (MPF), along with the kise Cdc2. The interaction of Cyclin B1 with Patched blocks MPF activity, blocking progression through the G2/M transition. Shh binding leads to degradation of Ptc-1, release of Cyclin B1, and entry of the cyclin B1 into the nucleus. Patched acts as a tumor suppressor by blocking MPF activity. Blockade of the Hedgehog pathway by cyclopamine demonstrated the therapeutic potential of Hedgehog inhibition in the treatment of some cancers. |
| Species | Homo sapiens |
| nCoCo Score | 276 |
| Base PAG ID | WAG000418 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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